Focus on enoxaparin

Update on the safety and bioequivalence of biosimilars – focus on enoxaparin

Generic forms of chemically-derived drugs must exhibit chemical identity and be bioequivalent in healthy human subjects. The use of generic drugs results in a considerable savings of healthcare expenditures. Biologic drugs are produced in living systems or are derived from biologic material and extend beyond proteins to include antibodies, polysaccharides, polynucleotides, and live viral materi...

Enoxaparin Dermatosis

Four days after she began enoxaparin, a tender, firm, hemorrhagic vesicular rash, ranging from 0.1 to 0.8 cm, developed on her calves bilaterally (Figure 1). The rash bled with minimal trauma and dried into crusted scabs. These lesions were distant from the enoxaparin injection sites on her upper arms. Laboratory results included: hemoglobin, normal; leukocytes, 19×109/L; platelets, 353,000/μL;...

Inhixa, INN enoxaparin sodium

Thorinane, INN enoxaparin sodium

Enoxaparin-Induced Skin Necrosis

DESCRIPTION A previously well 96-year-old woman underwent a hemiarthroplasty of her right hip. She was treated postoperatively with subcutaneous injections of enoxaparin for venous thromboembolic (VTE) prophylaxis, as per hospital protocol. She developed 2 areas of skin necrosis at the location of the injection sites 4 days postoperatively.